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  Propolis: Clinical Research Review
Please read below some of the clinical trials that have been undertaken on the health
benefits and medicinal effects of Propolis.
  Anti-microbial activity of propolis:
A study on the antimicrobial activity of propolis states: "results indicate that Propolis,
showed significant antimicrobial activities against Gram-positive bacteria and yeasts,
Enterococcus faecalis was the most resistant Gram-positive bacterium, bacteria, and
Candida albicans the most resistant yeast. Propolis showed synergism with selected
antibiotics, and displayed ability to enhance the activities of antifungals. The shown
antimicrobial potential of propolis alone or in combination with certain antibiotics and
antifungals is of potential medical interest
.i

Bacterial effects of Propolis for Upper Respiratory Infections:
A German Study states: Propolis is a natural product of bees which exhibits an
antimicrobial effect. In the study the existence of a bactericidal effect against several
strains isolated from patients with infections in their upper respiratory tracts is
demonstrated. In light of the use of propolis as a therapeutic agent in natural medicine
for common colds and inflammatory processes this effect is discussed
.ii

Anti-oxidant activity of Propolis:
An Italian Study shows: Propolis possesses several biological activities such as
antiinflammatory, immunostimulatory, antiviral and antibacterial. In this work, we have
investigated the antioxidant activity of a propolis extract deprived of caffeic acid
phenethyl ester (CAPE). Propolis extract (with and without CAPE) and its active
components showed a dose-dependent free radical scavenging effect, a significant
inhibition of xanthine oxidase activity, and an antilipoperoxidative capacity. Propolis
extract with CAPE was more active than propolis extract without CAPE. The
experimental evidence, therefore, suggests that CAPE plays an important role in the
antioxidant activity of propolis.iii

Antibacterial effect of Propolis on Oral Bacteria & Dental Plaque:
An Israeli study states: Propolis demonstrated an antibacterial effect both in vitro on
isolated oral streptococci and in the clinical study on salivary bacterial counts.iv
A study for the USA states: The experimental mouthrinse (containing Propolis) reduced
the IP concentration in dental plaque by 61.7% compared to placebo (p < 0.05). An
experimental mouthrinse containing propolis SNB-RS was thus efficient in reducing
supragingival plaque formation and IP formation under conditions of high plaque
accumulationv

Protective action of Propolis on Cartilage:
An Italian study states: We observed that this natural compound and its active principle,
caffeic acid phenethyl ester (CAPE), were able to contrast the harmful effects of
IL-1beta.Our data clearly demonstrated the protective action of propolis in cartilage
alteration, that appears greater than that elicited by indomethacin, commonly employed
in joint diseases.vi

 
i Stepanovic S, Antic N, Dakic I, Svabic-Vlahovic M, Department of Bacteriology, Institute of Mcrobiology and Immunology, School of Medicine, University of Belgrade, Serbia. Microbiology Res. 2003; 158(4):353-7
ii Focht J, Hansen SH, Nielsen JV, van den Berg-Segers A, Riezler R. Bioscientia, Institute for Laboratory Medicine, Moers, Fed. Rep. of Germany, Arzneimittelforschung. 1993 Aug;43(8):921-3. Bactericidal effect of propolis in vitro against agents causing upper respiratory tract infections
iii Russo A, Longo R, Vanella A. Department of Biochemistry, Medical Chemistry and Molecular Biology, University of Catania, V.le A. Doria 6, 95125, Catania, Italy. Fitoterapia. 2002 Nov;73 Suppl 1:S21-9. Antioxidant activity of propolis: role of caffeic acid phenethyl ester and galangin
iv Steinberg D, Kaine G, Gedalia I. Department of Oral Biology, Faculty of Dentistry, Hebrew University-Hadassah, Jerusalem, Israel. Am J Dent. 1996 Dec;9(6):236-9. Antibacterial effect of propolis and honey on oral bacteria.
v Koo H, Cury JA, Rosalen PL, Ambrosano GM, Ikegaki M, Park YK. Department of Dentistry, University of Rochester Medical Center, Rochester, NY, USA. Caries Res. 2002 Nov-Dec;36(6):445-8. Effect of a mouthrinse containing selected propolis on 3-day dental plaque accumulation and polysaccharide formation vi Cardile V, Panico A, Gentile B, Borrelli F, Russo A. Department of Physiological Sciences, University of Catania,
v.le A. Doria 6, 95125, Catania, Italy Life Sci. 2003 Jul 11;73(8):1027-35. Effect of propolis on human cartilage and
chondrocytes.

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